the retn gene rs1862513 polymorphism as a novel predisposing marker for familial acne vulgaris in a pakistani population

نویسندگان

sabir hussain department of biosciences, comsats institute of information technology, islamabad-46000, pakistan

ahmad faraz department of surgery, government post graduate medical institute, lady reading hospital, peshawar, pakistan

tahir iqbal department of internal medicine, shifa college of medicine, shifa international hospital, h-8/4, islamabad, pakistan

چکیده

resistin (retn), recently found to be relevant to inflammation and inflammatory disorders. we, therefore, aimed to investigate the potential role of retn gene polymorphism in pathogenesis of acne vulgaris with familial history. we investigated the retn-420c/g polymorphism in 180 patients with acne vulgaris and 180 healthy individuals in a case-control association analysis. in this study, we also investigated the heritability of the retn susceptible allele from 140 trio families with acne affected offspring. the genotyping was performed by polymerase chain reaction and direct dna sequencing.the retn-420c/g polymorphism was significantly associated with acne in patients compared with healthy controls (p=0.014). the minor allele g at -420 was more prevalent in cases vs. controls (p=0.002). the retn-420c/g polymorphism was significantly associated with severity of acne vulgaris in patients (p=0.0097). the results of a transmission disequilibrium test revealed a significant association between the retn-420c/g polymorphism and acne vulgaris (p<0.001). for the first time in the literature, to our knowledge, we demonstrate a significant association of the retn-420c/g functional polymorphism with familial acne vulgaris.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The RETN gene rs1862513 polymorphism as a novel predisposing marker for familial Acne vulgaris in a Pakistani population

Resistin (RETN), recently found to be relevant to inflammation and inflammatory disorders. We, therefore, aimed to investigate the potential role of RETN gene polymorphism in pathogenesis of acne vulgaris with familial history. We investigated the RETN-420C/G polymorphism in 180 patients with acne vulgaris and 180 healthy individuals in a case-control association analysis. In this study, we als...

متن کامل

The RETN gene rs1862513 polymorphism as a novel predisposing marker for familial Acne vulgaris in a Pakistani population

Resistin (RETN), recently found to be relevant to inflammation and inflammatory disorders. We, therefore, aimed to investigate the potential role of RETN gene polymorphism in pathogenesis of acne vulgaris with familial history. We investigated the RETN-420C/G polymorphism in 180 patients with acne vulgaris and 180 healthy individuals in a case-control association analysis. In this study, we als...

متن کامل

polymorphism in the il-8 gene promoter and the risk of acne vulgaris in a pakistani population

interleukin-8 (il-8) is a well-known inflammatory chemokine and suggested to be involved in the development of acne vulgaris. this study investigates il-8 plasma levels in acne patients and healthy controls and the molecular basis for the regulation of the il-8 gene in a pakistani population.patients with acne vulgaris (n=264) and healthy individuals (n=264) were enrolled in this investigation....

متن کامل

Polymorphism in the IL-8 Gene Promoter and the Risk of Acne Vulgaris in a Pakistani Population.

Interleukin-8 (IL-8) is a well-known inflammatory chemokine and suggested to be involved in the development of acne vulgaris. This study investigates IL-8 plasma levels in acne patients and healthy controls and the molecular basis for the regulation of the IL-8 gene in a Pakistani population. Patients with acne vulgaris (n = 264) and healthy individuals (n = 264) were enrolled in this investiga...

متن کامل

Genetic Polymorphism of CYP2C19 in Pakistani Population

CYP2C19 polymorphism is associated with pretreatment drug response prediction, metabolism, and disposition. Pakistan consists of a population comprising of various ethnic groups residing in different regions of the country each claiming diverse ethnic origins. The identification of CYP450 genotypic composition of these populations is therefore necessary to avoid adverse drug reactions in these ...

متن کامل

Genetic Polymorphism of CYP2C19 in Pakistani Population

CYP2C19 polymorphism is associated with pretreatment drug response prediction, metabolism, and disposition. Pakistan consists of a population comprising of various ethnic groups residing in different regions of the country each claiming diverse ethnic origins. The identification of CYP450 genotypic composition of these populations is therefore necessary to avoid adverse drug reactions in these ...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of basic medical sciences

جلد ۱۸، شماره ۵، صفحات ۵۲۶-۵۲۸

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023